The Stone the Builders Rejected : how New York saved natural penicillin antibiotics from the British

In London in 1928 , Sir Alexander Fleming discovered natural penicillin as a potential antibiotic but then rejected it - saying it would only be useful if chemically synthesized and even then only as a external antiseptic.

Sir Howard Florey at Oxford, together with chemist Sir Ernst Chain, took up Fleming's challenge to chemically synthesize penicillin and for a decade - from the late 1930s to the late 1940s, his lab chased the chimera of totally synthesized commercial penicillin without any success.

All three men - and these three men alone - got the Nobel Prize for penicillin .

This despite the fact that the penicillin that actually saves lives is still natural in origin, not synthetic , and is a general antibiotic and not a external antiseptic --- never before or since has abject failure been so grandly rewarded !

Memo to RAMZI YOUSEF : Wartime Manhattan gave the world's first penicillin shots --- as well as the world's first A-bomb

Manhattan's first ever penicillin shots (75 years ago next  October 16th 2015) were a deliberate act of provocation by Dr Martin Henry Dawson.

Penicillin shots across the bow against the Allied medical establishment for using the excuse of war medicine preparation to dismiss efforts of social medicine directed at the poor and minorities.

He felt that penicillin should be deliberately given a high enough wartime production priority to be able to give penicillin to all those in wartime dying from lack of it .

This would serve as a very public rebuttal to the Axis who felt only the 'fit' from the 'fittest' nations deserved medicine, food and indeed life itself.

Wartime penicillin for all the Allied armed forces and civilians , as well as for Allied and enemy POWs, and the people in Neutral lands ,  even via the Red Cross into the occupied lands and eventually used to save the lives of former enemies.

The aftershock from Manhattan's first penicillin shots radiated out in ever-widening circles.

The then modest biological firm of Pfizer , from Brooklyn , was quickly recruited by news of those historical first shots and began helping out Dawson.

But first Dawson had to demonstrate success against a hitherto invariable fatal disease (SBE) to really suggest what penicillin might do if it was mass produced.

 He did so, starting in November 1942, by 'going off the reservation' and used some OSRD controlled penicillin to save a group of women dying of SBE - something the OSRD strictly forbade - which meant abandoning them to a certain death.

But the astounding success he had with SBE was enough evidence for Dawson's former patient , industrialist Floyd Odlum , to suggest to his boss at the powerful (the New Deal-oriented) War Production Board (WPB) that it greatly up the original production proposed by its rival Vannevar Bush's OSRD .

But Big Pharma sat on its hands, convinced it could make much more money for a much smaller investment (and without a need to learn new skills) when it had synthetic (aka patentable) penicillin instead of this dangerous natural penicillin - which could be made by any competitor.

Such as Dawson - whose modest hospital pilot plant was for several months , the world's "biggest" penicillin producer !

Dawson had certainly convinced a fellow colleague and fellow WWI vet, Dr Rudolph (Rudy) N Schullinger in the Surgical Service of his hospital.

Rudy went overseas in mid 1942 with the CUMC's wartime Second General Hospital unit to Oxford England. Dawson had full-blown Myasthenia Gravis (MG) by that date or he would have been the Lab Chief for that military hospital.

Rudy Schullinger tried very hard to get some of the OSRD's penicillin sent into the European Theatre of War so he could both treat wounded American troops in wartime and contribute the results to the ongoing research pool.

Despite repeated entreaties the OSRD would have done of it !

Thankfully Schullinger's protests finally did pull some some penicillin out of the hands of stay-at-home civilian researchers and into the frontlines (before the war ended).

Though it was only to be used to treat american troops , he broke Regulations and used a good deal of it to save the life of a British soldier dying of the same disease Dawson was trying to cure - endocarditis !

(Dawson's "Acting Up" was infectious .)

Then another former patient , med resident Dr Dante Colitti , threw an emotional spanner in the works - suggesting to the parents of a dying two year old girl from Queens called Patty Malone that they call up Citizen Hearst's biggest paper and beg them to get penicillin the OSRD was denying her.

The Hearst media empire's emotional accounts of rushing the penicillin to the little girl with "just seven hours to spare" gripped first a nation and then a world.

It gripped - in particular - the hearts of Mr and Mrs John L Smith . They had lost a young girl to meningitis that mass produced penicillin - as Dr Dawson always insisted - could easily have cured.

The normally hyper-cautious Smith - the boss of Pfizer - now threw all caution to the wind - ordering his firm to build the world's first really big penicillin plant in as few months as a 24/7 schedule could produce.

Bolder yet - he decided to use the penicillin allocated to his firm to do synthetic studies (to secure a share of the future patents) to save the lives of people in New York  with SBE that his government was refusing to save.

A mysterious woman (probably the otherwise very upright Gladys Hobby) would arriving offering bottles of penicillin without labels to doctors like Ward J MacNeal and Leo Loewe with the oblique suggestion it might just help their SBE patients - and then disappear.

At the time it seemed clear to people inside Big Pharma that Smith had recklessly threw away a certainty of big future profits for Pfizer, just to help save the lives of a few worthless nobodies.

But his - and our - salvation lay in the most unlikeliest of all places : the former eugenic laboratories at Cold Spring Harbour in Long Island , once one of the intellectual godfathers to the Nazi holocausts agains Jews, Slavs and the 'unfit'.

For several years, its new (non-eugenically oriented) director Milislav Demerec had pleaded in vain with Vannevar Bush's OSRD to let him help develop more productive natural strains of penicillin-producing penicillium.

But the OSRD - like Florey and Fleming in England - had its heart set on a man-made synthetic triumph with penicillin - they had no intention to share the glory with anyone small and weak  - let alone microbes.

Once again , the WPB saved the day. Its Office for Production Research and Development (OPRD) had about one hundredth the budget and influence of Vannevar Bush's better known Office for Scientific Research and Development (OSRD).

But the OPRD had street smarts in spades and it wisely gave a tiny amount of money and a lot of morale-boosting support to Demerec's and the spectacular results has repaid that debt a million fold and more ever since.

Demerec gave the penicillium spores a nasty sunburn under an ordinary tanning lamp - most died from the radiation.

But a few survived and were soon producing ten - then one hundred and today 50,000 times as much penicillin from the same amount of feedstock as Fleming's original strain (and Fleming's was an extraordinarily good natural producer !)

Yet Demerec remains the most unsung among all the unsung true heroes of the wartime penicillin story : a case once again where the moral scum - not the moral cream - rises to the top of the fame charts.

Now Dawson's team wasn't the only team in New York thumbing their nose at Big Pharma and Big Medicine by starting a penicillin grow-op.

A doubting doctor John Mahoney out on Staten Island Marine Hospital questioned the OSRD's claim that penicillin couldn't cure syphilis .

With unofficial help from Dawson's team they started growing their own and tested their theory on "Easter" Bunnies (as they told their innocent children) that they kept in their home garages over the Easter holidays !

The public clamour from Doctor Mom for "more penicillin now !" that had started with the story of Patty Malone really took off with the thought that with penicillin families need no longer be threatened with VD from errant husbands.

We can't negate the atomic Manhattan Project and Hiroshima.

But Manhattan Penicillin ,the other Manhattan Project , can point with pride to the fact that 80% of the penicillin landed on D-Day (in its first ever mass clinical trial) came from Pfizer's Marcy Avenue Brooklyn plant and that plant went on to supply the biggest chunk of the world's penicillin for the rest of the war.

So much penicillin that America - not the Britain of Nobel prize winners Florey and Fleming ( who were still chasing the decade old chimera of synthetic penicillin and only then mass production) - supplying most of the penicillin for the Allied, Neutral, occupied and Enemy lands.

And that in turn ushered in a Pax Americana based on diplomatic gifting of abundant New York penicillin.

Dawson's dream of abundant - non-patented - penicillin cheap enough to help all has come true - it is life-saving too cheap to meter, lifesaving far cheaper than bottled water.

It has beaten back age old diseases kept endemic by residing among remote and poor people not reached by clean water, adequate food and proper health care.

As a result a sort of herd immunity has occurred as ten billion of us since 1940 have indirectly had better health from seeing diseases like Rheumatic Fever fade from sight.

No, the 250,000 lives lost at Hiroshima and Nagasaki can never be re-gained by actions in other areas - but I think I have offered up evidence to terrorists like Ramzi Yousef and others that wartime Manhattan was at least as much from Venus as it was from Mars.

And if Manhattan citizens are too modest to blow their own horn about its decisive role in making cheap abundant penicillin available to ALL in a world tired, huddled and wretched - then the rest of us should do it for them.

We can't continue to let a terrorist like Ramzi Yousef be the last word on Manhattan's wartime role ....

Ramzi Yousef - and the British - mustn't be allowed to forge the last word on Manhattan's wartime role

Yes, a thousand times yes, many of the events that birthed the Atomic Bomb that killed 250,000 did in fact occur on Manhattan and in the surrounding Greater New York City area.

But there was another wartime Manhattan project which has saved far far far more lives than the A-Bomb ever took : a wartime project a lot more from Venus than from Mars, a project more Emma Lazarus than Gordon Gekko.

Manhattan began by birthing the first ever use of antibiotics on October 16th 1940.

Columbia University Medical Centre associate professor and medical doctor Martin Henry Dawson aimed to see the wartime development of "Penicillin-for-All" : for friend, enemy and neutral alike.

Yes, even in -- especially in -- a Total War against an opponent who thought only the 'fit' of the 'fittest races' deserved medicine , food and life.

The Anglo American scientific-medical establishment hotly opposed Dawson but his tiny team of misfits and unfits persisted.

Dawson told the world of his first ever use of penicillin as an antibiotic in February 1941 and again in May of that year.

The second one caught the attention of the American media and through a big story in the New York Times , the eye of a then small citric acid producer in Brooklyn called Pfizer who soon began a prolonged engagement with Dawson's project.

Then thanks to Dawson's former patient (and Manhattan resident) Floyd Odlum , one agency (the War Production Board (WPB) -- out of many for the Allies -- caught his vision too.

They ordered that enough American wartime penicillin to be be produced to save all those dying in the Allied civilian and military worlds , with enough left over to save many of those dying in the rest of the world as well.

But Big Pharma sat on its hands, hoping public domain natural penicillin might soon be replaced by high profit patented synthetic penicillin.

But when another former patient of Dr Dawson,  Dr Dante Colitti from the Bronx , broke the embargo on going to the popular press to plead for government penicillin for dying baby Patty Malone of Queens.

Soon a local Manhattan news story broke big - first going stateside (thanks to the newspaper chain of Citizen Hearst) and then going international , despite the war censorship.

(Good News travels fast --- never faster than in the middle of a Bad News War.)

Pfizer boss John L Smith was moved because the plight of the little Patty because it reminded him so much of the unhappy circumstances surrounding the un-necessary meningitis death of his daughter Mary Louise. (Penicillin usually quickly cures cases of frequently fatal meningitis.)

She had died basically because the (healthy) Alexander Fleming couldn't get off his fanny in the early 1930s to make penicillin in the same way that the (terminally ill) Dawson had done in the 1940s.

John L and his wife must have had a serious heart to heart pillow talk about this one night because soon the normally extremely cautious Smith had thrown off all traces.

'Damn the rest of Big Pharma, and damn petty government regulations forbidding Pfizer and Smith from giving away secret penicillin to keep people alive.'

He ordered in Klieg Lights and put the firm on a 24/7 mad rush to complete the world's first really big penicillin plant.

He was moved as well by all the successes Dawson was having in curing endless kinds of diseases with penicillin - and by the unexpected discovery made in a Staten Island hospital that penicillin quickly and safely cured the age old scourge of syphilis.

John L was big Dodgers fan - he owned part of the club - and in the early summer of 1944 the baseball team stiffed.

Despite this , Brooklyn still scored big on an extended road trip : Omaha, Utah, Juno , Gold and Silver.

For 80% of the penicillin that landed on D-Day came from Pfizer's converted ice-cube plant on Marcy Avenue in "The-Borough-That-Builds" -- and for the rest of the war Pfizer supplied by far the biggest portion of the world's penicillin.

Obviously more than just a tree grew green in Brooklyn that summer.

Britain had discovered penicillin and done almost all the work on it until Dawson's first ever injections of penicillin-the-antibiotic on October 16th 1940.

But the attitude of the leading British researcher, Oxford's Dr Howard Florey , was directly opposed to Dawson's humanitarian values.

He wanted penicillin kept secret and used only as a weaponized medicine , something that would give Allied troops a surprise advantage over the Germans.

Allied civilians and POWs , along with the dying in the occupied countries, the neutrals and the enemy would just have to wait at the back of the bus.

In addition, Florey (and Fleming) banked all his hopes on the chimera of cheap synthetic penicillin - something still not achieved - or ever likely to be!

So as American natural penicillin (and not British synthetic penicillin) flew by plane all over the the world, very highly publicized in the global media, to save dying children in Allied and Neutral countries (some like Australia a former close ally of Britain and ironically , the home of Florey !) , something very important for our post-war world happened.

Pax Britannica , sustained up to now by collective memories the British bravery under the Blitz, faded and was replaced by the new Pax Americana.

Or perhaps Pax Penicillia ? Pax Manhattana ? Pax New York ?

When Dawson died of his terminal disease in the spring of 1945 , just after the death of FDR and just before those of Mussolini and Hitler, his passing got a moment of respectful recognition for all he wrought.

But Dawson safely dead, Fleming and Florey got all the credit ever since though they had signally failed to produce any synthetic penicillin for either the war effort or for the world's dying.

The were aided by Britons , all of them - from top to bottom , unconsciously determined to recover something from a costly war they supposedly won.

Ever since then, the British have rivalled the Russians in the number of important wartime inventions and discoveries that only they supposed did the fundamental work in --- even though the hard evidence says many people in many nations made important contributions over many decades.

Penicillin , along with radar and the jet , occupies the very Parthenon of this false-memory syndrome.

If left to British science - and left to Churchill's Conservative British government - the war or the postwar would never have seen cheap abundant penicillin produced all over the planet.

Endless endemic diseases would not have been knocked back - millions would have died - with billions suffering ill health.

Come on up Manhattan and New York - on October 16th 2015 take a deep bow for your role in wartime's humanitarian "Penicillin-for-All" - you fully deserve it !

And Ramzi Yousef and all your terrorist ilk - Manhattan penicillin has saved far more of your kinfolk than your bombs will ever kill - at least try and show a hint of respect.

Don't be like the ungrateful British....

Manhattan's OTHER project : how seven lives 'unworthy of life' improved the lives of seven billion of us ...

WWII as a triumph of small science

Conventional accounts of the atomic Manhattan Project and of the development of wartime penicillin strongly emphasize that they were the first of what has come to be called Big Science  --- something that is taken as the norm for today's science.

But in fact much of the science of the atomic bomb and atomic energy was actually done by very small teams working with very little money and home made equipment - it was the engineering aspects that were the truly massive part of that particular project.

With regards to wartime penicillin it was much the same : small science ,  not Big Science.

One must remember that wartime penicillin's powerful impact came not merely from its unique scientific characteristics --- ie that it was first (and to some extent, the last) broad spectrum but non-toxic bacterial killer.

Its biggest impact really came from the fact that wartime penicillin G was unexpectedly inexpensive and and unexpectedly widely available for such a potent lifesaver.

This is because a very cheap and abundant (because it was non-patented) lifesaver could save far more lives than any very expensive patent-limited lifesaver could ever do.

And then we all benefit.

Because by a sort of a global herd immunity when even the poorest people living in the most remote places on Earth are cured of killer strains of disease, we in wealthier places tend also to never see those diseases again.

This is because such diseases have been around seemingly for ever as endemic diseases  --- all by surviving in geographic cum cultural pockets, among those considered too poor or too worthless to treat properly medically.

So the true miracle of wartime penicillin was more moral than scientific in nature.

Its miracle lay in the unexpected success of a small band of seven physically challenged individuals in convincing the American public that penicillin should be made available to all Americans who need it to survive.

Convincing them that their Allied leaders should not just producing a small amount of penicillin as secretively as possible, just so they could use it as a weapon of war to give D-Day's front line Allied commanders an advantage over their Nazi counterparts.

The Allies had - because of dysgenic fears - far too few infantrymen to really defeat the Nazis or the Japanese in a hard fight.

(And the few infantrymen they did have were more 4F than 1A, in comparison to the average military serviceman !)

The Allies instead hoped to quickly re-use most of their relatively small forces of infantry when they got moderately severely wounded - by employing advanced medical efforts - so their frontline rifleman could get a second and third crack at being killed in combat.

(As a member member of an reserve infantry unit, may I quickly say ---- "Oh joy !!")

If these medical efforts failed , it meant many more 'decent, middle class, white, Protestant men' would end up dying in the PBI (Poor Bloody Infantry) and this was seen as an eugenic mistake that the Allied cultural elite was not about to repeat from WWI.

If their scheme worked, they would keep the best of their breed safe from the trenches and still have a big advantage over the enemy.

Because , by contrast, they figured the average German infantry, when moderately severely wounded , was out for half a year - while the average Japanese under such circumstances simply died of their wounds.

Their thinking was that that much bigger Axis armies, with much of their troops in hospital beds, couldn't defeat assaults from much smaller Allied Corps , if the Corps had most of their troops in fighting trim.

Because the medically convincing details of the lifesaving results of penicillin were only known by the Allied medical establishment , the  hard pressed Nazis and Japanese hadn't given the development of penicillin (which they had read about in the public scientific literature) much of a priority.

If these lifesaving successes could continue to be kept out of the medical and public media until D-Day , only the Allies would have abundant patented (secret) penicillin to return their wounded to combat much quickly than had traditionally been the case.

D-Day would spill the beans soon enough , but long before the Germans and Japanese chemists had broken the penicillin patent and gone into mass production,  the war would be over.

The Seven Crips

The seven argued - by contrast - that the war to defeat Hitler was as much moral as military.

Germany was the moderately big schoolyard bully and Poland was the moderately small schoolyard victim.

Hitler had gotten away with his bullying because the rest of the world - which vastly out-numbered and out-gunned him, had not intervened against his bullying but instead talked up the virtues of non-intervention in European 'schoolyard squabbles'.

Not my words - rather the shameful words of endless newspaper editorials and 'statesmen' the world over in the early 1940s.

The seven said we must not just talk The Atlantic Charter talk (the Allied declaration that said all - even the smallest and weakest and most valueless - had an absolute right to life and security).

The seven said we must make sure our own Allied actions don't echo the Nazi's counterclaims.

(That the strongest are morally justified in denying the weakest and smallest the right of life and succour.)

But instead the Allies were actually and openly "Code Slowing" tens of thousands of mostly young, mostly poor and minority people.

People with the SBE version of endocarditis - SBE being the final - hitherto terminal - disease that made childhood Rheumatic Fever such a terror.

The SBEs were considered to be so useless that they couldn't even be recruited to work in the war industries , let alone be in the military.

So no wartime penicillin was to be wasted on them and they were to be left to die --- for two reasons.

The unimportant reason was that currently penicillin was still in limited supply and the SBE were below the lowest in priority, particularly as some cases of SBE did consume extremely large amounts of that limited penicillin.

The important reason was that SBE was regarded as the "Gold Standard" of intractable infections.

Any evidence that this new fangled 'penicillin' stuff could actually cure this famously most incurable of infectious diseases would tend to break the whole story of wartime penicillin wide open in the American news media.

And nothing (to paraphrase an old old adage of the pop music business) only 'breaks local' in America .

A big news story in America becomes a big news story worldwide - including in Japan and Germany, via friendly neutral diplomats in Washington.

The seven may have realized that while the Allied medical establishment won't easily bend on the issue of SBE and penicillin, it was also a hard position for the Allied elite to sustain publicly.

Letting young kids die needlessly merely on account of being judged 'life unworthy of life' would be a hard moral sell for the Allies warring against evil governments that basically did exactly the same thing.

Dr Dawson, the leader of the seven , decided to liberate ie 'steal' government controlled penicillin to successfully save five young women dying of SBE but his success was written out of the official report indicated penicillin test results.

And there it might of ended.

But for the fact that his successes and how this most unlikely of heroes was driven to steal to save lives had become the stuff of legend in New York's wartime-strengthened gossip grapevine among it tens of thousands of medical staffers.

A former patient of his, a fellow crip and fellow doctor named Dante Colitti , decided to emulate Dawson and saw to it that the fount of Yellow Journalism, Citizen Hearst's newspaper empire , covered his efforts from gavel to gavel.

The story - involving a terminally ill and terminally cute two year old toddler named Patty Malone - broke wide , broke stateside, broke worldwide.

Soon defeated in the court of public opinion by the formidable Doctor Mom, the Allies really opened the penicillin floodgates wide when Dawson's friend among Big Pharma , John L Smith of Pfizer , took up his cause and started producing it at levels a million times higher than Pfizer had done earlier.

Small science ?

Well the seven cripples had no government grants, had strong enemies rather than warm friends in high places and were - obviously - in poor physical vigour.

That they nevertheless brought the massed Allied governments - during a Total War - to their knees shows us all what sheer raw moral courage can do.

And that when we see those physically and mentally challenged as 'lives useless of life', they are anything but ....