Tuesday, July 22, 2014

Charlie and Miss "H" : The lazarus SBE patients of New York who beat the odds time and again to go on surviving

"Dead Men Waiting" or "Dead Women Waiting" is the way most staff in hospital regarded the the  patients in the Green Wards where earlier Rheumatic Fever sufferers with green strep in their heart valves waited out their turn to die.

Dr Martin Henry Dawson was determined that his hand-grown penicillin could help them to beat those odds and return these lazaruses to health , to give them a fair crack at enjoying their three score and ten here on Earth.

His struggle - partly against the disease , mostly against his own colleagues and wartime  government - cost him his own life , but in the end he succeeded against all measure of imagining , improving not just the future of the SBEs but of the entire world itself ....

Monday, July 21, 2014

Topical and local antiseptics versus life-saving antibiotics

When did 'the miracle of penicillin' , as opposed to just penicillin itself - really begin ?


If your life is in imminent danger from a massive bacterial infection your medical team may well use antibiotics topically (around the skin next to an opening in the skin) or locally (inside that opening).

But unless your doctors are criminally insane, they will not limit their use of antibiotics to these two methods.

Instead, their main weapon will be massive repeated doses of antibiotics given by needle (perhaps also by mouth).

Only by this method will the drug be able to travel quickly and thoroughly, via your bloodstream, to every single living cell in your body to engage any and all the offending bacteria all at once : a full-out , full-frontal attack.

So, to the public - and to all but pedantics in the medical world - giving 'antibiotics' without a qualifying adjective , really means the systemic (through the bloodstream to all the body) use of those drugs on human patients.

Penicillin had been occasionally used on patients for twelve years before that fateful October day in Manhattan - topically and locally with mixed results .

As well it had found use in hospital labs as a simple means to clear most regular oral bacteria from suspected samples of "flu" bacteria (sic).

But penicillin had never been used as an antibiotic (and nor had any other microbe-produced metabolite) in the common meaning of that word.

Not until Dr Martin Henry Dawson gave those first shots of hospital-grown penicillin to two young men dying of subacute bacterial endocarditis (the dreaded SBE) : October 16th 1940 , in Manhattan's CUMC (Columbia University Medical Centre) .

Thats when the miracle of penicillin truly began ....

Celebrating 75 years since the world's first penicillin shots - October 16 1940 Manhattan

There are people still alive who were the first in your community to ever receive a life-saving shot of penicillin.

I know this with great certainty because the first were very often young children who are still in their healthy seventies and eighties today.

Gather up their firsthand oral recollections while they are still alive and healthy - because at the 100th celebration of  the first ever penicillin shots they will all be dead and it will be too late.

I just missed my chance in my own community.

After my sister Tracy leal and her friend Lorna Innes notified me about an old newspaper story of a young girl surviving a life-threatening disease thanks to the first ever use of civilian penicillin in Halifax, I recollected the girl's name from my memory banks.

Now an older woman, I realized too late that she had just died , stabbed by her nephew.

Don't let my experience happen to you in your community.

Manhattan's penicillin has changed our world for the better - time for us to show some thanks back !


Help celebrate Manhattan's 75 years of life-saving penicillin Oct 16 1940 --- Oct 16 2015

Manhattan gave the world's first shots of life-saving penicillin , seventy five years ago next October 16th (2015).

And if Manhattan and New York City is too damn modest to blow its own horn , well we in the rest of the world should start by thanking Manhattan for all the good penicillin and other antibiotics have done for us in the three quarters of a century since.

Starting January first next year, let us start sending cards, phone calls and online* messages to the mayor of New York City to thank Manhattan for changing our world for the better forever.

http://www.nyc.gov/html/static/pages/officeofthemayor/contact.shtml

Yes, wartime Manhattan also birthed the A-Bomb.

But let us never forget that NYC not only produced most of the wartime world's penicillin, it also established the fundamental right of ALL in the world to cheap abundant life-saving penicillin in wartime.

And that was the best possible moral rebuke to those like the Nazis who advocated that medicine, food and life itself should only go to the fit of the fittest nations ....

Manhattan gives world's first penicillin shots Oct 16 1940 : celebrating 75 years of natural penicillin live-saving !

Dr Dawson as "the Donald McKay of Medicine" 


It all happened in a blindingly fast five weeks leading up to October 16th 1940.

 Dr Martin Henry Dawson went from reading vague hints about the clinical possibilities of natural penicillium juice to find its spores to inventing ways to quickly grow and concentrate the substance.

He then gave a needle of it to himself , for signs of human toxicity - and survived.

The very next day, October 16th 1940, Manhattan was the site of the world's first penicillin shots - as Dr Dawson injected his team's 'crude' natural penicillin into two 4F patients (a black and a Jew).

Seventy five years ago next year !
On the very day the rest of America began its 75 year old practise of registering all their 1A males.

And 25 years to the day when New York and North America first heard of the execution of nurse Edith Cavell in Belgium.

This news had galvanized Dawson to drop university and join a hospital unit to help poor bleeding Belgium.

Social medicine - the type that helps the 4Fs of this world - was being dropped that Fall to focus on War medicine for the 1As of the world .

Dawson saw this 'eugenic triage' as the civilized world doing exactly what the Axis already advocated - when they should be instead opposing it with every breath and every bone in their bodies.

The world's 4Fs were now his new poor bleeding Belgium.

If the Allied world won't move - then he would. And he did - changing our world for the better forever - until his dying breath four and a half years later.

Dawson was a man with a prominent broad jaw - he simply looked like the sort of person who when he got a bone between his teeth won't let go and would really run with it.

That was a sight an earlier Nova Scotia immigrant to New York , Donald McKay, (who had also set records for speedy results as the builder of the world's fastest ever clipper ships) would know full well.

For when his clippers had a full head of sail they too moved really really fast , with 'a bone in their teeth' as the old salts used to say :

If you want something to really move , hire a Bluenoser !





Sunday, July 20, 2014

Ramzi Yousef - and the British - mustn't be allowed to forge the last word on Manhattan's wartime role

Yes, a thousand times yes, many of the events that birthed the Atomic Bomb that killed 250,000 did in fact occur on Manhattan and in the surrounding Greater New York City area.

But there was another wartime Manhattan project which has saved far far far more lives than the A-Bomb ever took : a wartime project a lot more from Venus than from Mars, a project more Emma Lazarus than Gordon Gekko.

Manhattan began by birthing the first ever use of antibiotics on October 16th 1940.

Columbia University Medical Centre associate professor and medical doctor Martin Henry Dawson aimed to see the wartime development of "Penicillin-for-All" : for friend, enemy and neutral alike.

Yes, even in -- especially in -- a Total War against an opponent who thought only the 'fit' of the 'fittest races' deserved medicine , food and life.

The Anglo American scientific-medical establishment hotly opposed Dawson but his tiny team of misfits and unfits persisted.

Dawson told the world of his first ever use of penicillin as an antibiotic in February 1941 and again in May of that year.

The second one caught the attention of the American media and through a big story in the New York Times , the eye of a then small citric acid producer in Brooklyn called Pfizer who soon began a prolonged engagement with Dawson's project.

Then thanks to Dawson's former patient (and Manhattan resident) Floyd Odlum , one agency (the War Production Board (WPB) -- out of many for the Allies -- caught his vision too.

They ordered that enough American wartime penicillin to be be produced to save all those dying in the Allied civilian and military worlds , with enough left over to save many of those dying in the rest of the world as well.

But Big Pharma sat on its hands, hoping public domain natural penicillin might soon be replaced by high profit patented synthetic penicillin.

But when another former patient of Dr Dawson,  Dr Dante Colitti from the Bronx , broke the embargo on going to the popular press to plead for government penicillin for dying baby Patty Malone of Queens.

Soon a local Manhattan news story broke big - first going stateside (thanks to the newspaper chain of Citizen Hearst) and then going international , despite the war censorship.

(Good News travels fast --- never faster than in the middle of a Bad News War.)

Pfizer boss John L Smith was moved because the plight of the little Patty because it reminded him so much of the unhappy circumstances surrounding the un-necessary meningitis death of his daughter Mary Louise. (Penicillin usually quickly cures cases of frequently fatal meningitis.)

She had died basically because the (healthy) Alexander Fleming couldn't get off his fanny in the early 1930s to make penicillin in the same way that the (terminally ill) Dawson had done in the 1940s.

John L and his wife must have had a serious heart to heart pillow talk about this one night because soon the normally extremely cautious Smith had thrown off all traces.

'Damn the rest of Big Pharma, and damn petty government regulations forbidding Pfizer and Smith from giving away secret penicillin to keep people alive.'

He ordered in Klieg Lights and put the firm on a 24/7 mad rush to complete the world's first really big penicillin plant.

He was moved as well by all the successes Dawson was having in curing endless kinds of diseases with penicillin - and by the unexpected discovery made in a Staten Island hospital that penicillin quickly and safely cured the age old scourge of syphilis.

John L was big Dodgers fan - he owned part of the club - and in the early summer of 1944 the baseball team stiffed.

Despite this , Brooklyn still scored big on an extended road trip : Omaha, Utah, Juno , Gold and Silver.

For 80% of the penicillin that landed on D-Day came from Pfizer's converted ice-cube plant on Marcy Avenue in "The-Borough-That-Builds" -- and for the rest of the war Pfizer supplied by far the biggest portion of the world's penicillin.

Obviously more than just a tree grew green in Brooklyn that summer.

Britain had discovered penicillin and done almost all the work on it until Dawson's first ever injections of penicillin-the-antibiotic on October 16th 1940.

But the attitude of the leading British researcher, Oxford's Dr Howard Florey , was directly opposed to Dawson's humanitarian values.

He wanted penicillin kept secret and used only as a weaponized medicine , something that would give Allied troops a surprise advantage over the Germans.

Allied civilians and POWs , along with the dying in the occupied countries, the neutrals and the enemy would just have to wait at the back of the bus.

In addition, Florey (and Fleming) banked all his hopes on the chimera of cheap synthetic penicillin - something still not achieved - or ever likely to be!

So as American natural penicillin (and not British synthetic penicillin) flew by plane all over the the world, very highly publicized in the global media, to save dying children in Allied and Neutral countries (some like Australia a former close ally of Britain and ironically , the home of Florey !) , something very important for our post-war world happened.

Pax Britannica , sustained up to now by collective memories the British bravery under the Blitz, faded and was replaced by the new Pax Americana.

Or perhaps Pax Penicillia ? Pax Manhattana ? Pax New York ?

When Dawson died of his terminal disease in the spring of 1945 , just after the death of FDR and just before those of Mussolini and Hitler, his passing got a moment of respectful recognition for all he wrought.

But Dawson safely dead, Fleming and Florey got all the credit ever since though they had signally failed to produce any synthetic penicillin for either the war effort or for the world's dying.

The were aided by Britons , all of them - from top to bottom , unconsciously determined to recover something from a costly war they supposedly won.

Ever since then, the British have rivalled the Russians in the number of important wartime inventions and discoveries that only they supposed did the fundamental work in --- even though the hard evidence says many people in many nations made important contributions over many decades.

Penicillin , along with radar and the jet , occupies the very Parthenon of this false-memory syndrome.

If left to British science - and left to Churchill's Conservative British government - the war or the postwar would never have seen cheap abundant penicillin produced all over the planet.

Endless endemic diseases would not have been knocked back - millions would have died - with billions suffering ill health.

Come on up Manhattan and New York - on October 16th 2015 take a deep bow for your role in wartime's humanitarian "Penicillin-for-All" - you fully deserve it !

And Ramzi Yousef and all your terrorist ilk - Manhattan penicillin has saved far more of your kinfolk than your bombs will ever kill - at least try and show a hint of respect.

Don't be like the ungrateful British....

Saturday, July 19, 2014

Moral equivalency : the Nazi Hunger Plan and Allied bombing of civilians

Not enough has been said about how Axis and Allied in WWII were motivated - first and last - by fears of the dysgenic consequences of another WWI style war.

To Germans, WWI was lost by the British blockade starving an undefeatable (militarily) Germany into surrender.

Not that Germany hadn't tried to remain well fed by starving the peoples of the lands it occupied - but clearly, as civilian Germany had still gone hungry and lost the war, they hadn't been nearly rapacious enough.

That wasn't about to happen in WWII  ---- the Hunger Plan against the Slavs and the Holocaust against the Jews were proof of that.

The Allies saw WWI as an event where the fittest sons of the fittest families had disproportionally died in combat while the unfittest stayed well fed and safe at home - safe at home to multiply endlessly.


Conventional human-oriented (infantry and land battle oriented) war was thus not eugenic but dysgenic - killing the fit and preserving the unfit.

A new long range mechanical war directed at the enemy's civilian-operated war factories and their workers was the alternative.

Fit middle class men no longer crawled through the mud - they cooly pushed buttons at the complex command centre of large machines of war : battleships, submarines, bombers, tanks, long range rockets.

They aimed to hit hard and accurate from a long - safe - distance away.

By war's end, tanks could penetrate a half foot of hardened armour from a safe mile away and submarines had torpedoes that could travel 25 miles as could battleship shells.

In the air, bombs were routinely dropped from 25,000 or more feet up and rockets travelled up to 250 miles away to hit cities.

Morally, they were all just stand-off weapons for the squeamish.

Now naval and aerial blockade campaigns could ensure that hundreds of thousands of babies starved slowly to death 2500 remote miles away --- so as not to offend any (diminishing) middle class sensibilities.

German 1A troops were kept fit and fed by starving to death the 4Fs of Eastern Europe.

Britain and America had hoped to never have their 1A troops directly engage 1A Axis troops on German and Japanese home territory.

Killing enough 4F Germans and Japanese by direct civilian bombing and indirect naval blockades should cause the enemy 1A army to surrender first without any need for your own 1A army to be bloodied.

It didn't work in Germany but it sort of did in Japan - after the American A-bomb, in combination with an old-fashioned infantry-led direct land assault by the Russians, tipped the scales.

My stance ?

If you have to defeat an evil-doer by extreme force ( and Hitler, Stalin and Tojo fit that bill) and you have greatly superior population numbers - as the Allies ALWAYS did , the answer is clear.

The means that produces the least deaths among your side and the enemy's side of conscripted soldiers and conscripted civilians is a massive infantry led direct assault on the enemy's home territory on simultaneous multiply fronts.

Britain ,France - even America - were not willing to overwhelm the Axis by large armies - if much/most of the people in those victorious large armies were their colored colonials.

(Let remind you that the largest volunteer army history has ever seen yet was the WWII Indian army.)

If Indian concerns had been addressed and India conscripted at WWII (let alone WWI) levels , the Indian Army might have cowed even Hitler into a negotiated peace rather than be overwhelmingly defeated by 10 million dark Indian infantrymen on German soil.

In WWII, we would rather have lost to fellow white racists than to win by means of a multi-colored armed forces that would give those coloreds the moral means to demand independence or basic human rights.

If the war had to be won by means of people we considered unfit - we'd rather just lose --- the unfits' role in the war were simply to be pliant blockade and bombing victims on the other side.

Luckily , one group of unfits - Dawson's unfits - rejected that role.

Instead these 4Fs repeatly rescued dying 1A soldiers with big needles of cheap, plentiful "Penicillin-for-All" ....